Drug targeting to the diseased brain

Drug targeting to the diseased brain

Category

Biomedicine

Available online

16 Nov 2013

Found in Edition

2013, Volume 4, 420-429

Format

Review article
The delivery of hydrophilic drugs to the brain is limited by the various barriers in the brain. In this respect, the blood-brain barrier BBB is the most important barrier because it functions as a physical and metabolic barrier represented by the endothelial cells of brain capillaries. In order to treat brain diseases, drugs must pass the BBB by targeting them to internalizing transport systems at the BBB to overcome the BBB. In this paper, we summarize some approaches that may be successful for clinical application. The applicability of Cross Reacting Material CRM197 as a receptor-mediated targeting agent - particularly under disease induced circumstances - seems favorable and effective.

Subject

Mathematical Statistics

Keywords

blood-brain barrier, receptor-mediated drug targeting, disease-induced drug targeting

Download

Only members can download articles. Sign up as member
Already registered? Login here
ABOUT THE AUTHORS

A.G. de Boer (1)

BBB Research Group, Dept. Pharmacology, LACDR, University of Leiden, Leiden The Netherlands and AI-Cure BV, Leiden, The Netherlands

G.J. Schenk (1)

Dept. Anatomy and Neurosciences, Sec. Clinical Neuroscience, VU University Medical Center, Amsterdam, The Netherlands
COMMENTS

No comments yet.

ADD COMMENT

Only members can comment on articles. Sign up as member
Already registered? Login here







Sign up as member
Forgot your password?

Anton de Kom Universiteit van Suriname

Telesur
Telesur Mobiel Nederland
TeleG
TeleI

Join us on Facebook